A Nobel Prize presented to experimental physicist Leon Lederman in 1988 is to auction at Nate D Sanders.
The lot is valued in excess of $325,000, with the sale due to close on May 28.
Lederman was awarded the medal for his discovery of a new subatomic particle, the muon neutrino, in 1962.
The other was biologist James Watson, one of the discoverers of the DNA genome, who sold his medal at Christie's last year.
It was bought by Russian billionaire Alisher Usmanov for $4.1m and returned to Watson with the words: "Dr Watson's work contributed to cancer research, the illness from which my father died.
"It is important for me that�Ǫ the medal will stay with the person who deserved it. I wouldn't like the medal of the distinguished scientist to be an object on sale."
Bidding on a handwritten letter by second US president John Adams starts at $75,000.
Adams served as president from 1797-1801. The letter was written during the War of 1812 and indicates Adams own thoughts and feelings on the conflict.
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