A 1931 Alfa Romeo 6C 1750 Supercharged Gran Sport Spider is expected to top Bonhams' Grand Marques du Monde au Grande Palais auction in Paris with an estimate of $2.1m-3.4m.
The lot was formerly the property of Italian opera singer and racing driver Giuseppe Campari (1892-1933).
After his death, it was raced extensively at some of the biggest meets in Europe. During the 1980s it was heavily restsored.
Bonhams describes the car as "without question one of the most desirable pre-war Alfa Romeos currently available."
Several Aston Martins are available at the February 5 sale, including a 1965 DB5 Cabriolet valued at $1.9m-2.3m and a 1962 DB4 Cabriolet at $1.4m-1.9m.
Philip Kantor, Bonhams' European head of motoring, commented: "The DB5 model is synonymous with the James Bond franchise, and the DB4C came to a treacherous end over the alpine cliff edge in The Italian Job.
"Unusually, the pair are both left-hand drive convertibles, making them ultra rare and highly sought-after. They feature beautifully designed Italian coachwork from Touring's Superleggera, successfully crafted on what is otherwise a very British car.
"At Bonhams we're seeing great demand in the trend for cars of the 1960s".
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