Lost in the Dust, an exhibition and sale of work by South African artist John Meyer, is to open at Bonhams on July 22.
The show features a series of narrative paintings set during the Anglo-Boer war.
At the show's opening on July 21, Bonhams will auction a canvas by Meyer - with proceeds to go to the African wildlife conservation project Tusk.
Charlie Mayhew, CEO of Tusk, comments: "We are delighted that John Meyer has donated a unique, never before seen piece in aid of conservation and protection of wildlife.
"At Tusk we work to forge a link between the preservation of Africa's natural heritage, its landscapes and wildlife, and the future of its land and people."
Prince William, one of the project's patrons, comments: "I have been captivated by Africa ever since my first visit as a teenager, to the extent that I now consider it as my second home.
"To me, there is something awe-inspiring and magical about what most embodies this diverse continent: its people, landscape and wildlife….
"I was initially drawn to Tusk by its innovative and holistic approach and its unwavering certainty that conservation is as much about people and community programmes as it is about wildlife protection."
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