A fine example of Banksy's Love is in the Air image is up for grabs at Bonhams London on June 27.
The £100,000 ($160,000)-estimated piece is the highlight of the auction house's Contemporary Art and Design sale.
Signed and dated in 2006, the spray paint on canvas was acquired by the consignor directly from the secretive street artist in the same year - a factor which will no doubt enhance its value.
Alan Montgomery, a specialist in contemporary art at Bonhams, commented: "Prices for spray paint canvases by Banksy in our recent auctions demonstrate that his works are more popular than ever with high-profile art collectors, reflecting the continuing fascination with his art amongst the public as a whole.
"This Love is in the Air is one of his best-known images, and we expect significant interest in this lot."
Banksy's Slave Labour mural, controversially removed from a London street, sold for more than £750,000 ($1.1m) earlier this month, according to Bloomberg.
The Banksy word record stands at $1.9m, achieved by his Keep It Spotless at a Sotheby's auction in December 2008.
The auction will also feature a Damien Hirst spin painting, valued at £40,000 ($62,000), as well as a Tracey Emin sculpture of her cat, Docket, valued at £3,000 ($4,700).
Two Gilbert and George postcards will sell with £8,000 ($12,000) and £15,000 ($23,000) high estimates, respectively.
You can view our wide range of art for sale here.