A Patek Philippe ref 5004A stainless steel wristwatch with a spilt-second chronograph is valued at $515,718-644,685 ahead of a sale at Antiquorum in Hong Kong.
The lot will headline the auction house's Rare Modern Complicated Wristwatches sale.
Only 50 examples of the watch, which features a perpetual calendar, Moon phases and 24-hour indication, were produced during its limited run in 2011.
Founded in 1851, Patek Philippe is known as the world's foremost producer of high-end watches, and holds the record for the most valuable watch sold at auction.
It was set by ref 1527, a gold chronograph wristwatch from 1943, which sold for $5.5m at Christie's Geneva in 2010.
More recently, a titanium 5004T achieved $3.9m at the Only Watch charity auction in Monaco in 2013.
A Patek Philippe ref 3939H platinum watch with a one-minute tourbillon repeater is estimated at $348,129-438,385.
It was made in 2008 and features a platinum deployment clasp.
Also featured is a Patek Philippe ref 5004J wristwatch, which carries an estimate of $322,342-399,704.
It comes with a perpetual calendar and 24 hour indication, alongside a range of other features.
The watch is the only known example of its reference to feature yellow gold and a black dial. This is the first time it has appeared at auction since it was purchased in 2011.
Sign up to our free newsletter for the latest on watches and other collectibles.