A Lou Gehrig signature model bat he used during 1935 is expected to make around $300,000-400,000 at Christie's.
Gehrig was made captain of the New York Yankees that year and took them close to winning the World Series, behind the Detroit Tigers.
He finished the year with a batting average of .329, the highest on the team.
The bat features patina and staining from extensive use and displays Gehrig's number (4) carved into the knob.
Just a couple of years later, in 1938, Gehrig would start to display symptoms of ALS - which would also become known as Lou Gehrig's Disease.
This would cut his career short in 1939.
He would receive a two minute standing ovation from fans at Yankee Stadium following his farewell speech.
A bat Jackie Robinson used while playing for the Brooklyn Dodgers in 1955 is also valued at $300,000-400,000.
The Dodgers clinched victory in the World Series that year, although it was actually Robinson's worst year on record.
He maintained a batting average of just .256 and managed to take just 12 bases. The following year he quit the game to become vice president of coffee chain Chock full o'Nuts.
A very rare Shoeless Joe Jackson used bat (circa 1917-1921) is expected to make up to $700,000.
Love sport? Click here to take a look at our incredible range of sports memorabilia for sale.
Please sign up to our free newsletter to receive exciting news about sports memorabilia auctions.