The trophy for the 1970 Grand National, won by Gay Trip, is up for sale at Graham Budd Auctions in London on November 4.
It carries an estimate of £10,000-15,000 ($16,070-24,105).
The 9k gold and onyx trophy features a large elongated cross surmounted by the figure of Pegasus.
Gay Trip was the fourth National winning horse trained by Fred Rimmell. He was the top weighted entrant of the race and there were doubts over his stamina.
In 2007, the trophy for the 1910 Grand National, won by Jenkinstown, sold for £10,000 ($16,070) at Graham Budd.
Red Rum is the only other horse besides Gay Trip to have won the race at top weight, a feat set in the 1977.
We have a racing plate worn by Red Rum in his unprecedented third Grand National victory in 1977, widely regarded as one of the greatest moments in racing history.
A pair of royally presented racing plates worn by Persimmon and Diamond Jubilee, from 1896 and 1900, respectively, will also star in the sale.
They feature engraved plaques laid on red velvet with a gilded border.
A racing plate worn by Dancing Brave when winning the King George VI and Queen Elizabeth stakes at Ascot in 1986 is valued at £1,500-2,000 ($2,410-3,214).
A highly successful racehorse, Dancing Brave won eight of the 10 races that he entered.
You can view more of our horse racing memorabilia here.
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