The annual celebration of classic and significant cars sees the Grand Prix two-seater, previously owned by former director of the Bugatti owners club Jack Perkins, go on sale with a guide value of £400,000-500,000 ($651,619-814,487).
Other noteworthy lots include another unique Bugatti, the 1926 Type 37 - complete with a manual start up crank - expected to sell for £160,00 ($260,582), and a 1954 Aston Martin DB2, estimated to sell for £500,000-700,000 ($651,619-1,140,031).
Known to be one of only two styled by famous Italian Giovanni Bertone, founder of the Carrozzeria Bertone automobile company in 1912, the electric blue Aston Martin is a car lover's dream.
Jack Perkins, who died in 1992, bought the 1925 Bugatti car in 1950 for £60 after finding it in Nottinghamshire. His plan was to customise and make it the fastest possible 35B, resulting in it being equipped with a methanol burning engine and ultra-streamlined body.
The work paid off, as it set a time of 52.15 seconds at Prescott, home to the Bugatti owners club, in 1954.
The car is clearly built for racing, with its large wheels and minimalist frame, and would take pride of place as part of any motor museum of classic car collection.
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