A 1984 Ducati TT1 ridden by Pablo Real for Team Leoni is valued at $165,000-185,000 ahead of Bonhams' Las Vegas Motorcycle Auction.
The sale will take place on January 9.
The lightweight bikes carry a 748cc engine and 16 inch tyres, and proved a hit among enthusiasts in the 1980s after claiming victories in Formula 1, Battle of the Twins and other high profile races.
Only 60 were produced, placing them among the rarest bikes that Ducati ever built.
The series was the last racing bike legendary chief designer Fabio Tagliona worked on before his retirement in 1989.
This example was campaigned during the 1980s by Pablo Real, a solid racer who won the 1991 Pro Twins GP1 national championships.
Its importance as a racing artefact, however, lies in its connection to Reno Leoni - a test rider for Ducati who moved to the US to work as a tuner and was instrumental in setting up the Battle of the Twins event.
It was previously held in the collection of the Silverman Museum in Santa Fe, New Mexico.
A restored 1973 Ducati 750SS could make $130,000-150,000.
One of the most beloved sport bikes in history, the 750SS realised a staggering victory at Imola in 1972, with the two Ducati team riders achieving first and second place.
Only 400 were ever produced, with many extensively modified over the intervening years - making the example in the sale exceptionally rare.
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