A 2015 McLaren P1 will provide the headline lot of Bonhams' Scottsdale auction on January 28.
The car carries an estimate of $1.9-2.2m.
The P1 is the successor to the legendary F1, which was the world's fastest production car during the late 1990s and early 2000s.
The P1 is capable of speeds up to 247mph - around 5mph faster than the F1. It features a hybrid V8 engine.
Bonhams explains: "The P1 is a masterpiece of space and Formula One technology, combined with inspired design applied to automotive engineering supreme…
"Beyond the incredible performance this car supplies, the unique special features of this particular P1 and last-of-the-line status are sure to leave people impressed.
"Being that all 375 examples were allocated nearly immediately after being released, very few occasions come up to acquire a P1. The intelligent collector will seize this opportunity."
A 1962 Mercedes-Benz 300SL roadster is expected to make $1.5m-1.8m.
The lot is one of around 1,800 produced between 1957 and 1963. It was shipped to America soon after it rolled off the production line.
It remains in exceptional condition and includes its original engine.
Next year's Scottsdale is shaping up to be one of the biggest yet, with Boyd Coddington's French Connection set to auction at Barrett-Jackson, and a 1965 "Shark Nose" Ferrari set to cross the block at Russo & Steele.
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