The sale will be split into two sessions. Friday 14 will focus on Banknotes & Bonds; while the following day will feature both Coins & Medals and Autographs & Manuscripts.
Friday's sale promises a diverse collection of rare Georgia obsoletes, selling alongside the "unparalleled" small-size currency collection of James M Wilson.
Among Saturday's coinage treasures are European Hammered Gold and a British Crown Collection, with numerous examples of desirable US Type numismatic rarities.
But especially astonishing is the inclusion of a George Washington signed document among the sale's autographs.
The highly sought-after and rare, partly engraved document is signed by Washington as president of the Society of the Cincinnati at Mount Vernon in December 1785.
In the letter, Washington confirms that John H Wendell Esquire, late Captain in the 1st New York regiment, is a Member of the Society. The document is valued at $10,000.
Earlier this year, a letter by George Washington to his nephew Bushrod in 1778 in which he endorses the idea of the United States Constitution sold for $3.2m at Christie's - so the 1785 Washington letter will certainly be one to watch.
Rare autographed manuscripts featuring the likes Thomas Edison, Andy Warhol, Dwight Eisenhower and silent screen legend Charlie Chaplin will also appear at Spink Smythe's sale, along with old baseball and other sporting manuscripts.
Other rare and value signed documents featuring the autographs of Andy Warhol, Charlie Chaplin and Babe Ruth are also available on the market, and can be viewed here.
Meanwhile, Paul Fraser Collectibles currently holds another historic and valuable George Washington autograph, for sale as part of our American Presidents Portfolio of exceptionally rare documents and signatures.