Over 500 items are to be sold on October 16-17 including film and music memorabilia and artworks, alongside clothing and furniture from the private collection of Barbra Streisand.
Some of the choicest clothes include two vintage Christian Dior outfits.
One was worn by the singer to the Grammys in 1986, where she collected one of her nine awards, for Best Pop Vocal Female Performance. There are also outfits worn for her 1994 and 2000 music tours.
There will also many dresses and outfits from her films, notably Funny Lady, for which she received an Oscar for Best Actress, and the multiply Oscar nominated films Yentl and Prince of Tides. There is also a range from the popular Meet the Fockers series of films.
Streisand is also selling a baby grand piano and a phonograph she bought when she was eighteen.
The artworks include a painting by Kees van Dongen, a set of Edward Curtis photographs and various pieces of Art Deco and Oriental rugs.
Streisand has won more awards in the entertainment industry than most: along with the nine Grammys, she has four Emmys, two Oscars and a Special Tony Award.
The proceeds will go primarily to the Streisand Foundation, which champions women's, children's, political and environmental causes.
Some other charities, including the William Jefferson Clinton Foundation, will also benefit.