As well as screening all 14 of Burton's feature films, the exhibit will show many paintings, drawings, puppets and even sculptures, many of which pre-date and in some cases helped Burton on his way to creating the films.
"His doodles, sketches, drawings and paintings are the raw material from which he draws inspiration as a filmmaker." said Glenn Lowry the museum's director.
Burton, aged 50, is known for making quirky films, and 11 out of 14 of them have been Oscar nominated.
He now lives in London, but says growing up in suburban Burbank, California forced him to tap into his artistic side and escape through his imagination.
"There wasn't a real kind of artistic culture, where I got anything, it was from TV or movies," he said.
The exhibition runs from September until April, 2010. Burton's latest film, Alice in Wonderland, is expected to appear in the cinemas around this time.