As well as being a much-loved poet, Edward Lear (1812-1888) was also a prolific artist.
The 19th Century Paintings auction at Bonhams, London on July 13 features a topographical scene of Bethlehem which Lear completed from sketches he made while travelling in the Middle East.
Investors can get their hands on the piece for an estimated £50,000-80,000.
In 1858, Lear spent three months touring Jerusalem, Petra, Bethlehem, Hebron and Lebanon, after receiving a commission from Lady Waldegrave for two works including a view of Jerusalem.
The preliminary sketches he made during his travels were later employed in a number of oil paintings. It is believed that this work was commissioned by Leonard Rowe Valpy, a noted collector of contemporary painting.
"We are delighted to offer for auction this rare Lear view of Bethlehem, a place of huge religious and historical significance, and the artist's only major oil of the subject," said Charles O'Brien, the head of 19th Century Pictures at Bonhams.
A gibberish letter from Lear featuring a miniature picture of a dog sold for £2,160 at Bonhams earlier this year.