LS Lowry's Three Children will be among the top lots of Sotheby's Made in Britain sale in London on March 16.
The work appears to be a study and features three of Lowry's trademark matchstick figures against a white background.
It's valued at £40,000-60,000 ($57,895-86,842).
Lowry is among the UK's best loved painters, famous for his idiosyncratic scenes of northern life. His painting The Football Match sold for a record £5.6m ($8.1m) in a 2011 sale.
Patrick Heron's Violet Painting with Orange, Lemon and Black: April - May 1964 is offered with an identical estimate of £40,000-60,000 ($57,895-86,842).
The painting is a prime example of the influence of the New York expressionists on Heron's work, which can be seen from the mid-1950s onwards.
Sotheby's comments: "Paintings such as Violet Painting With Orange, Lemon and Black: April - May 1964 are symbolic of a new found confidence in British art, inspired as it was by American art but sure, too, of its ambitions.
"The colours that Heron adopted during the mid-60s certainly reflect an awareness of both Pop and American Hard-Edge Abstraction, both of which - albeit to different ends - used colour in explosive fashion."
The sale will also feature work from Lucian Freud, Grayson Perry and Henry Moore among others.
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