LS Lowry's Entrance to the Dwellings (1933) will lead an auction of British and Irish art at Bonhams.
It's expected to make £600,000-800,000 ($866,880-1.1m) when it crosses the block in London on June 15.
The work depicts the gateway that stood at the entrance to the Salford Improved Industrial Dwellings in Manchester.
The estate was home to a great many factory workers and labourers and Lowry painted it often.
It was demolished in the 1960s.
Bonhams comments: "Painted at a time when Lowry's career as an artist began to gain traction, Entrance to the Dwellings is an accomplished and characterful oil…
"Lowry found in this particular gateway an image that proved to be of great consequence, and he used it with subtle differences in a series of paintings and drawings which span four decades."
Lowry's record is £5.6m ($8m), set for The Football Match (1949) in a 2011 sale.
Three Lowry paintings owned by the late British singer and TV personality Cilla Black will sell at Sotheby's in June.
Ben Nicholson's Painted Relief (1941) is also on offer at Bonhams, with an estimate of £400,000-600,000 ($577,580-866,370).
The work was executed in Carbis Bay, St Ives; where Nicholson moved with his wife Barbara Hepworth and their three children in 1939.
Two sculptures by Barbara Hepworth that stood in her former school are to auction in London in June.
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