Faith Ringgold's Double Dutch on the Golden Gate Bridge could sell for $150,000-250,000.
It will highlight a sale of African American art at Swann Auction Galleries in New York on April 7.
The quilt is one of five in Ringgold's famous Woman on a Bridge series, which depicts women floating above some of America's most iconic bridges.
Swann explains: "Each quilt in the series is a powerful visual expression of uplifting women, with bright images of dancing, playing, music and being free.
"About the Woman on a Bridge series, Ringgold has said 'my women are actually flying; they are just free, totally. They take their liberation by confronting this huge masculine icon—the bridge...'"
Ringgold was born in Harlem in 1930 and studied art education at New York City College.
She began creating her pictorial quilts after seeing a collection of Tibetan thangkas (cloth paintings) in Amsterdam's Rijksmuseum on a visit to Europe in the 1970s.
Last year Ringgold's Quilt of Life sold for $461,000 in Swann Auction Galleries' sale of writer Maya Angelou's art collection.
The present lot is only the second Ringgold quilt ever to come to auction (Quilt of Life was the first).
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