Donald Judd's Untitled (Bernstein 93-1) (1993) will cross the block at Christie's New York on November 12 with a $7m-9m estimate.
The work was executed mere months before his death and stands as one of the artist's most significant ever auctioned.
Part of the Stacks series, the piece comprises a set of brass boxes mounted with coloured Plexiglas.
Jonathan Laib, Christie's senior specialist in post-war and contemporary art, commented: "Donald Judd's Stacks are arguably the most successful, recognizable and transcendent pieces within his significant body of work.
"Judd's visual vocabulary, pared down to its essentials, allowed for a wide variety of expressive material combinations".
Judd (1928-1994) is considered a key figure in the development of minimalism, although he vocally rejected the term. His auction record stands at $14.1m, set for Untitled (DSS 42) (1963) at Christie's New York last year.
Laib explained: "There has been a steady increase in market appreciation for Judd's most important and brilliantly realized works.
"This masterwork, which could break the current record for the artist at auction, is available on the market for the first time since its original acquisition in 1993."
The sale will also include two important works by Andy Warhol (Triple Elvis and Four Marlons), which are expected to realise a combined $130m.
We have an incredible range of art and photography memorabilia available.
Please sign up to our free newsletter to receive exciting news about art and antiques auctions.