Cheri Samba's J'aime la couler will be among the top lots of Bonhams' African art sale in London on October 15.
The work is valued at £25,000-35,000 ($38,888-54,444).
Samba was born in the Democratic Republic of Congo (DRC) and began working as an advertising artist in Kinshasa during the early 1970s.
He often paints self-portraits, explaining: "Whether or not the subject of the paintings involves me directly, I still prefer to appear in them.
"Why should I put someone else's face instead of my own when I'm the one painting, they're my ideas and I'm the one deciding on the subject and comments?"
His unique and surreal work is increasingly in demand in the West. Traitement Apollo, one of his best-known paintings, sold for $43,926 at Christie's Paris in 2008.
Goncalo Mabunda's Weapon Throne is expected to make £6,000-9,000 ($9,326-13,990).
Mabunda is a Mozambique-based artist who began making furniture and masks out of deactivated weapons following the nation's 1992 cease-fire.
Bonhams explains: "The chairs are parodies, the barrels and grenades making for an uncanny and useless talismanic object, a technique which eloquently becomes metaphor for the futility of war."
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