Banksy's Donkey Documents (2007) is to headline a street art auction with a $400,000-600,000 valuation.
The lot will auction at Julien's in Beverly Hills on September 30.
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The piece is one of the artist's most expressly political works, having been painted directly on to the wall separating Israel from Palestine.
Julien's explains: "The controversial mural depicts a donkey having its identification papers checked by an armed Israeli soldier, mocking the stringent security measures enforced by the Israeli Government.
"Banksy's location choice, timing, and subject matter draws parallels with the donkey depicted in the well-known Biblical Christmas story that transported Mary into Bethlehem where she gave birth of Jesus."
Another piece by Banksy, I Remember when all this was Trees (2010), is valued at $200,000-400,000.
The lot was originally painted on a wall at Detroit's Packard automobile factory and references the city's industrial decay.
Banksy's work is hugely popular among collectors. His auction record stands at $1.9m, set by Keep it Spotless - a collaboration with Damien Hirst.
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