A model 1834 Mississippi Original Accession #33.69 train from the Museum of Science and Industry will be sold at Bonhams.
The piece will join a number of other replica trains from throughout American history in a sale at the Simeone Foundation in Philadelphia on October 5.
Bonhams explains: "An original artefact, it is a rare surviving example of a British-built steam locomotive in America and dates to 1834…
"This is believed to be the first locomotive in the South and certainly the very first locomotive to operate in the state of Mississippi.
"It went on to be used by the Confederate Army and subsequently, after capture, by the Union Army during the Civil War.
"It is therefore a machine of national importance - not just to America's transportation history and the critical formative years the railroad played in nation building, but also to the Civil War and to the technological link between Great Britain and the United States and the Industrial Revolution itself."
Other models include a 1929 replica of the 1829 "John Stevens" - the first American locomotive.
Please sign up to our free newsletter to receive exciting news about antique auctions.